Spermatid nucleus differentiation

Across TCGA patient cohorts, RNA activity of the Spermatid nucleus differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPC1, FBXL4, and ZBTB24, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spermatid nucleus differentiation activity versus EPC1 in UVM (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	EPC1 →	+1.025	+0.063	<.001	<.001	3	33
UVM	FBXL4 →	+1.253	+0.058	<.001	<.001	3	32
UVM	ZBTB24 →	+1.161	+0.057	<.001	<.001	3	32
UVM	SWT1 →	+1.134	+0.059	<.001	<.001	3	32
UVM	KHDC4 →	+1.188	+0.061	<.001	<.001	3	32
UVM	TCTE3 →	+1.068	+0.060	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007289 vs EPC1 — UVM

Explore this scatter interactively →