Spermatid nucleus differentiation

Across TCGA patient cohorts, RNA activity of the Spermatid nucleus differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNOT9, SUZ12, and TPX2_T369, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spermatid nucleus differentiation activity versus CNOT9 in BRCA (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNOT9 →	+0.212	+0.042	<.001	<.001	3	5
BRCA	SUZ12 →	+0.265	+0.037	<.001	<.001	3	5
BRCA	TPX2_T369 →	+0.861	+0.033	<.001	.008	3	5
OV	WRNIP1 →	+0.388	+0.040	.001	<.001	3	5
BRCA	CDK1 →	+0.600	+0.040	<.001	<.001	3	5
BRCA	NUP160 →	+0.180	+0.033	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007289 vs CNOT9 — BRCA

Explore this scatter interactively →