Spermatid nucleus differentiation

Across TCGA patient cohorts, RNA activity of the Spermatid nucleus differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C22orf23, LRRC32, and SCN11A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spermatid nucleus differentiation activity versus C22orf23 in LSCC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C22orf23 →	-0.613	-0.434	<.001	.001	3	3
OV	LRRC32 →	-1.035	-0.795	.006	<.001	3	3
GBM	SCN11A →	-0.253	-0.580	<.001	.002	3	3
GBM	SNORA59B →	-0.308	-0.769	<.001	<.001	3	3
BRCA	TNFRSF14-AS1 →	-0.394	-0.451	<.001	.001	3	3
BRCA	POPDC2 →	-0.404	-0.595	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007289 vs C22orf23 — LSCC

Explore this scatter interactively →