Spermatid nucleus differentiation

Across TCGA cell cohorts, RNA activity of the Spermatid nucleus differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASSF2, AQP5, and GRP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RASSF2 grouped by Spermatid nucleus differentiation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RASSF2 →	-0.298	-1.352	.001	.001	3	3
LUNG_SCLC	AQP5 →	-0.185	-1.288	.002	.002	3	3
LUNG_NSCLC_LUAD	GRP →	-0.185	-1.141	.009	.006	3	3
LUNG_SCLC	CD86 →	+0.137	+1.119	.002	.003	3	3
BONE	DHRSX →	-0.343	-1.475	.002	<.001	3	3
BONE	BCL2 →	+0.283	+1.423	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RASSF2 by Spermatid nucleus differentiation activity — LUNG_SCLC

Explore this box plot interactively →