Spermatid nucleus differentiation

Across TCGA cell cohorts, RNA activity of the Spermatid nucleus differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENOX1, POLK, and HES7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spermatid nucleus differentiation activity versus ENOX1 in LUNG_NSCLC_LUAD (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ENOX1 →	+1.032	+0.923	.006	.005	3	4
CNS	POLK →	-0.690	-1.241	.005	.001	3	4
BLOOD_Lymphoma	HES7 →	+1.086	+1.038	.009	.001	3	4
STOMACH	SLC35B3 →	-0.875	-1.185	.006	.003	3	4
KIDNEY	MME →	-3.274	-0.443	.001	.009	3	3
LUNG_NSCLC_LUAD	SLC16A9 →	-1.415	-0.823	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007289 vs ENOX1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →