Neuromuscular synaptic transmission

Across TCGA patient cohorts, RNA activity of the Neuromuscular synaptic transmission pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP13_S983, TPR_T2116, and DDX21_S121, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuromuscular synaptic transmission activity versus AKAP13_S983 in BRCA (Pearson r = -0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AKAP13_S983 →	-0.462	-0.031	<.001	.003	3	6
BRCA	TPR_T2116 →	-0.636	-0.070	.001	.001	3	5
BRCA	DDX21_S121 →	-0.700	-0.056	<.001	<.001	3	5
OV	AMBP →	+0.478	+0.039	.005	.008	3	5
OV	MRPS26 →	-0.311	-0.047	.002	.004	3	5
OV	MTURN →	+0.485	+0.054	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007274 vs AKAP13_S983 — BRCA

Explore this scatter interactively →