Neuromuscular synaptic transmission

Across TCGA cell cohorts, RNA activity of the Neuromuscular synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STN1, ADA, and GLA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STN1 grouped by Neuromuscular synaptic transmission-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	STN1 →	+1.063	+0.954	<.001	.002	3	4
SKIN	ADA →	+0.701	+0.984	.005	.002	3	4
LUNG_NSCLC_LUAD	GLA →	+0.779	+0.637	<.001	.001	3	3
LUNG_NSCLC_LUAD	ATXN1 →	-0.909	-0.755	.005	.005	3	3
LUNG_NSCLC_LUAD	FAM111B →	-0.868	-0.743	.001	.004	3	3
KIDNEY	SLC17A5 →	-1.717	-1.705	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STN1 by Neuromuscular synaptic transmission activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →