Neuromuscular synaptic transmission

Across TCGA cell cohorts, RNA activity of the Neuromuscular synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHRNB1, LEPROT, and FCHSD2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuromuscular synaptic transmission activity versus CHRNB1 in SOFT_TISSUE (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CHRNB1 →	+1.708	+0.099	<.001	<.001	3	9
LUNG_NSCLC_LUSC	LEPROT →	+1.337	+0.154	<.001	.001	3	7
STOMACH	FCHSD2 →	+1.180	+0.126	.005	.003	2	8
OESOPHAGUS	MLXIPL →	-1.692	-0.123	.001	.004	2	7
STOMACH	MUC3A →	-3.114	-0.206	<.001	<.001	3	6
BREAST	FAM155B →	-0.899	-0.095	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007274 vs CHRNB1 — SOFT_TISSUE

Explore this scatter interactively →