Neuromuscular synaptic transmission

Across TCGA cell cohorts, RNA activity of the Neuromuscular synaptic transmission pathway is significantly associated with the drug response of multiple features, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Dacinostat, TAK-715, and AZD3514, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Dacinostat grouped by Neuromuscular synaptic transmission-low versus -high activity in BONE.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Dacinostat →	+0.969	+0.700	<.001	.006	3	3
BONE	TAK-715 →	+1.022	+0.502	.006	.003	3	3
KIDNEY	AZD3514 →	-0.706	-0.509	.007	.009	3	3
BONE	Doxorubicin →	+1.320	+0.502	.001	.003	3	2
BONE	Etoposide →	+1.379	+0.502	<.001	.003	3	2
BONE	BAY-MPS1 →	+1.012	+0.517	.024	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Dacinostat by Neuromuscular synaptic transmission activity — BONE

Explore this box plot interactively →