Ensheathment of neurons

Across TCGA patient cohorts, RNA activity of the Ensheathment of neurons pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4, AKT3, and C1orf198, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ensheathment of neurons activity versus SEPTIN4 in GBM (Pearson r = 0.77).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN4 →	+0.806	+0.065	<.001	<.001	3	9
LSCC	AKT3 →	+0.378	+0.031	.008	.002	3	9
CCRCC	C1orf198 →	+0.604	+0.034	<.001	<.001	3	8
GBM	MAP1A →	+0.586	+0.066	<.001	<.001	3	8
GBM	MRPS34 →	-0.382	-0.071	<.001	<.001	3	8
OV	MRPS35 →	-0.440	-0.032	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007272 vs SEPTIN4 — GBM

Explore this scatter interactively →