Ensheathment of neurons

Across TCGA patient cohorts, RNA activity of the Ensheathment of neurons pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASF1B, DIAPH3, and ZDHHC23, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ensheathment of neurons activity versus ASF1B in OV (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ASF1B →	-0.827	-0.134	<.001	.003	3	3
COAD	DIAPH3 →	-0.489	-0.803	.002	.002	3	3
COAD	ZDHHC23 →	-0.457	-0.697	.001	.004	3	3
BRCA	DOT1L →	-0.498	-0.156	.003	.001	3	2
BRCA	HNRNPUL1 →	-0.334	-0.200	.006	.003	3	2
OV	PCCB →	-0.470	-0.192	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007272 vs ASF1B — OV

Explore this scatter interactively →