Ensheathment of neurons

Across TCGA cell cohorts, RNA activity of the Ensheathment of neurons pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LLGL2, PTPN11, and ACACA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LLGL2 grouped by Ensheathment of neurons-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LLGL2 →	+1.477	+0.174	.001	.003	3	4
BLOOD_Lymphoma	PTPN11 →	-0.653	-0.290	.002	.003	3	3
BLOOD_Lymphoma	ACACA →	-0.519	-0.290	<.001	.003	3	3
BLOOD_Lymphoma	SPDL1 →	-1.289	-0.395	.003	.002	2	4
URINARY_TRACT	PRSS12 →	+2.917	+0.280	<.001	.006	3	3
PANCREAS	MISP →	+2.232	+0.257	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LLGL2 by Ensheathment of neurons activity — BONE

Explore this box plot interactively →