Ensheathment of neurons

Across TCGA cell cohorts, RNA activity of the Ensheathment of neurons pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF391, HEATR1, and MICU3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ensheathment of neurons activity versus ZNF391 in SOFT_TISSUE (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZNF391 →	-1.415	-0.405	.008	.004	3	5
OVARY	HEATR1 →	-1.212	-0.950	<.001	.002	3	5
BREAST	MICU3 →	-0.874	-0.176	.007	.007	3	4
KIDNEY	SOD1 →	+0.735	+0.216	.001	.007	3	3
KIDNEY	SCARF1 →	-0.522	-0.231	.009	.003	3	3
OVARY	PRPSAP2 →	-1.201	-0.864	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007272 vs ZNF391 — SOFT_TISSUE

Explore this scatter interactively →