"Synaptic transmission, cholinergic"

Across TCGA patient cohorts, RNA activity of the "Synaptic transmission, cholinergic" pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCAT1, CRKL_Y207, and ZBTB37_S310, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Synaptic transmission, cholinergic" activity versus BCAT1 in COAD (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BCAT1 →	-0.834	-0.047	<.001	<.001	3	4
BRCA	CRKL_Y207 →	-0.473	-0.028	.001	.001	3	4
PDAC	ZBTB37_S310 →	+0.228	+0.018	.002	.007	3	4
CCRCC	RBM33 →	+0.109	+0.026	.004	.005	3	4
BRCA	RCN3 →	-0.502	-0.053	.001	<.001	3	4
BRCA	SCAMP1 →	+0.432	+0.047	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007271 vs BCAT1 — COAD

Explore this scatter interactively →