"Synaptic transmission, cholinergic"

Across TCGA patient cohorts, RNA activity of the "Synaptic transmission, cholinergic" pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UPK3B, SLC16A5, and TUBB6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Synaptic transmission, cholinergic" activity versus UPK3B in LSCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UPK3B →	+0.876	+0.292	<.001	<.001	3	4
CCRCC	SLC16A5 →	+0.414	+0.093	.006	.009	3	3
CCRCC	TUBB6 →	+0.562	+0.164	<.001	<.001	3	3
BRCA	PRELP →	+1.275	+0.205	.001	<.001	3	3
CCRCC	CACNB1 →	+0.358	+0.132	.002	.009	3	3
HNSC	KIAA0513 →	+0.526	+0.169	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007271 vs UPK3B — LSCC

Explore this scatter interactively →