"Synaptic transmission, cholinergic"

Across TCGA cell cohorts, RNA activity of the "Synaptic transmission, cholinergic" pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA9, TACR1, and BMP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANXA9 grouped by "Synaptic transmission, cholinergic"-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ANXA9 →	-0.350	-1.438	.001	.007	3	5
LUNG_NSCLC_LUSC	TACR1 →	-0.217	-1.214	.004	.004	3	4
BLOOD_Leukemia	BMP4 →	-0.306	-1.296	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	UQCRC1 →	-0.240	-0.395	.002	.001	3	4
SKIN	CCNI →	-0.132	-0.517	.009	.003	3	4
STOMACH	COL5A2 →	-0.260	-1.220	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANXA9 by "Synaptic transmission, cholinergic" activity — BLOOD_Myeloma

Explore this box plot interactively →