"Synaptic transmission, cholinergic"

Across TCGA cell cohorts, RNA activity of the "Synaptic transmission, cholinergic" pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRPRB, NGF, and KCNMB1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRPRB grouped by "Synaptic transmission, cholinergic"-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SRPRB →	-0.329	-0.626	.008	.002	3	3
LUNG_NSCLC_LUAD	NGF →	+0.200	+0.260	<.001	<.001	3	2
LUNG_NSCLC_LUAD	KCNMB1 →	+0.215	+0.206	.004	.002	3	2
LARGE_INTESTINE	PDE10A →	-0.269	-0.317	.006	.002	3	2
LARGE_INTESTINE	FKBP9 →	+0.210	+0.330	.004	.001	3	2
LARGE_INTESTINE	NIPSNAP2 →	-0.341	-0.328	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRPRB by "Synaptic transmission, cholinergic" activity — OVARY

Explore this box plot interactively →