Neurotransmitter secretion

Across TCGA patient cohorts, RNA activity of the Neurotransmitter secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COIL_T303, PDPK1, and SYT7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter secretion activity versus COIL_T303 in LSCC (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	COIL_T303 →	-0.579	-0.026	.006	<.001	3	6
GBM	PDPK1 →	+0.236	+0.065	<.001	<.001	3	6
GBM	SYT7 →	+1.128	+0.087	<.001	<.001	3	5
GBM	TGFB1I1 →	-0.444	-0.084	<.001	<.001	3	5
OV	CYLD →	+0.360	+0.017	<.001	.001	3	5
LSCC	DDX18 →	-0.337	-0.031	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007269 vs COIL_T303 — LSCC

Explore this scatter interactively →