Neurotransmitter secretion

Across TCGA patient cohorts, RNA activity of the Neurotransmitter secretion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFTPA1, RFTN1, and KIF15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter secretion activity versus SFTPA1 in LSCC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SFTPA1 →	+2.911	+0.409	<.001	.005	3	3
LUAD	RFTN1 →	+0.485	+0.203	.003	.009	3	3
UCEC	KIF15 →	-0.746	-0.199	.001	.008	2	4
LUAD	LRRK2-DT →	+0.943	+0.174	<.001	.004	3	3
UCEC	SPA17 →	+0.598	+0.229	.003	.006	3	3
PDAC	PLS3 →	-0.361	-0.511	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007269 vs SFTPA1 — LSCC

Explore this scatter interactively →