Neurotransmitter secretion

Across TCGA patient cohorts, RNA activity of the Neurotransmitter secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FRK_S40, SCRIB_S1475, and LRRK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter secretion activity versus FRK_S40 in LUAD (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FRK_S40 →	+0.508	+0.258	<.001	.001	3	4
LUAD	SCRIB_S1475 →	+0.412	+0.256	<.001	<.001	3	3
COAD	LRRK2 →	+1.104	+1.018	.003	.004	2	4
LSCC	RPP30 →	-0.214	-0.438	<.001	.003	3	2
UCEC	RPS2_S264 →	-0.709	-0.248	<.001	.001	3	2
OV	RYBP_S89 →	-0.963	-0.217	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007269 vs FRK_S40 — LUAD

Explore this scatter interactively →