Neurotransmitter secretion

Across TCGA cell cohorts, RNA activity of the Neurotransmitter secretion pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIN7B, EFEMP1, and PHLDB2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter secretion activity versus LIN7B in SOFT_TISSUE (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LIN7B →	+1.239	+0.073	<.001	<.001	3	10
BONE	EFEMP1 →	-3.858	-0.084	.006	<.001	3	10
SOFT_TISSUE	PHLDB2 →	-3.229	-0.074	<.001	<.001	3	10
BONE	ANKRD1 →	-3.542	-0.100	.005	<.001	3	10
BONE	HEG1 →	-2.866	-0.088	.002	<.001	3	10
SOFT_TISSUE	ABCA3 →	+2.229	+0.067	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007269 vs LIN7B — SOFT_TISSUE

Explore this scatter interactively →