Rho protein signal transduction

Across TCGA cell cohorts, RNA activity of the Rho protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCL2, IL10RA, and TYSND1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLCL2 grouped by Rho protein signal transduction-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PLCL2 →	+1.460	+1.579	.005	<.001	3	4
LUNG_NSCLC_LUSC	IL10RA →	+0.335	+1.544	.001	.001	3	4
CNS	TYSND1 →	+0.845	+0.902	.004	.007	3	4
BLOOD_Lymphoma	ZNF571 →	+1.409	+0.234	<.001	.002	3	4
KIDNEY	ARHGEF26 →	+1.159	+1.083	.003	<.001	3	3
KIDNEY	CMTM7 →	+1.050	+1.150	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLCL2 by Rho protein signal transduction activity — SOFT_TISSUE

Explore this box plot interactively →