Rho protein signal transduction

Across TCGA cell cohorts, RNA activity of the Rho protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCAT, MAPKAPK3, and DOCK8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rho protein signal transduction activity versus MCAT in BLOOD_Leukemia (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MCAT →	+0.617	+0.271	.002	<.001	3	4
PANCREAS	MAPKAPK3 →	+1.258	+0.918	.005	.006	3	4
BLOOD_Lymphoma	DOCK8 →	+2.676	+0.352	.001	.001	3	4
BLOOD_Lymphoma	ARHGDIB →	+4.818	+0.295	<.001	<.001	3	4
BLOOD_Lymphoma	RHEBL1 →	-2.032	-0.266	<.001	<.001	3	4
BLOOD_Lymphoma	GAS1 →	-4.338	-0.392	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007266 vs MCAT — BLOOD_Leukemia

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