Tyrosine phosphorylation of STAT protein

Across TCGA patient cohorts, RNA activity of the Tyrosine phosphorylation of STAT protein pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UNC13D, JUNB, and S100A12, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tyrosine phosphorylation of STAT protein activity versus UNC13D in UCEC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UNC13D →	+0.465	+0.057	.001	.009	3	8
OV	JUNB →	+0.437	+0.046	<.001	<.001	3	8
COAD	S100A12 →	+1.692	+0.043	<.001	<.001	3	7
GBM	SKAP2 →	+0.739	+0.093	<.001	<.001	3	7
UCEC	STK10 →	+0.327	+0.072	.003	.001	3	7
COAD	AZU1 →	+1.267	+0.040	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007260 vs UNC13D — UCEC

Explore this scatter interactively →