Tyrosine phosphorylation of STAT protein

Across TCGA patient cohorts, RNA activity of the Tyrosine phosphorylation of STAT protein pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCR5AS, HCST, and LY96, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tyrosine phosphorylation of STAT protein activity versus CCR5AS in HNSC (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCR5AS →	+0.592	+0.146	<.001	.001	3	6
BRCA	HCST →	+0.920	+0.226	<.001	<.001	3	5
BRCA	LY96 →	+0.664	+0.184	<.001	.002	3	5
HNSC	P2RY13 →	+0.714	+0.149	<.001	<.001	3	5
HNSC	CCL8 →	+0.955	+0.153	.006	.004	3	5
HNSC	CD244 →	+0.712	+0.152	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007260 vs CCR5AS — HNSC

Explore this scatter interactively →