Tyrosine phosphorylation of STAT protein

Across TCGA cell cohorts, RNA activity of the Tyrosine phosphorylation of STAT protein pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASP8AP2, BMP4, and ZNF621, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CASP8AP2 grouped by Tyrosine phosphorylation of STAT protein-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CASP8AP2 →	+0.598	+1.091	<.001	.003	3	4
PANCREAS	BMP4 →	-0.266	-1.306	<.001	<.001	3	4
PANCREAS	ZNF621 →	+0.261	+1.056	<.001	<.001	3	4
OESOPHAGUS	KNDC1 →	-0.251	-1.136	<.001	.002	3	4
STOMACH	STX1A →	-0.387	-1.325	.003	.003	3	4
BREAST	CDK6 →	+0.130	+0.698	.006	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CASP8AP2 by Tyrosine phosphorylation of STAT protein activity — PANCREAS

Explore this box plot interactively →