JNK cascade

Across TCGA patient cohorts, RNA activity of the JNK cascade pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C11orf45, CDC42SE2, and SAP30BP, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, JNK cascade activity versus C11orf45 in OV (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C11orf45 →	+0.726	+0.994	<.001	.006	3	2
BRCA	CDC42SE2 →	+0.430	+0.897	.006	.001	3	2
BRCA	SAP30BP →	+0.638	+0.973	.008	.001	3	2
BRCA	MIR7848 →	+1.214	+0.777	.003	.004	3	2
BRCA	MTMR1 →	+0.705	+0.723	.002	.002	3	2
COAD	TRIP4 →	+0.303	+0.282	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007254 vs C11orf45 — OV

Explore this scatter interactively →