JNK cascade

Across TCGA cell cohorts, RNA activity of the JNK cascade pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAMP1, FRMPD2, and PRR15L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VAMP1 grouped by JNK cascade-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VAMP1 →	+0.997	+0.613	.001	.005	3	4
URINARY_TRACT	FRMPD2 →	-0.391	-1.283	<.001	.002	3	4
BONE	PRR15L →	-0.108	-1.257	.007	.001	3	4
STOMACH	ETHE1 →	-1.570	-0.253	<.001	.004	3	3
LARGE_INTESTINE	GPR160 →	-2.495	-0.678	<.001	.005	3	3
URINARY_TRACT	EID2B →	+1.214	+1.647	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VAMP1 by JNK cascade activity — LARGE_INTESTINE

Explore this box plot interactively →