JNK cascade

Across TCGA cell cohorts, RNA activity of the JNK cascade pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK40, RNF168, and TMEM250, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, JNK cascade activity versus STK40 in BLOOD_Leukemia (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	STK40 →	+0.664	+0.493	.001	.006	3	4
SOFT_TISSUE	RNF168 →	+0.543	+0.936	.003	.008	3	4
BONE	TMEM250 →	+0.927	+0.444	.007	.003	2	5
LUNG_NSCLC_LUSC	SIRT4 →	+0.597	+0.631	.002	.003	3	4
PANCREAS	JPH1 →	+1.348	+0.285	.009	.004	3	4
KIDNEY	RAB8B →	+1.396	+0.586	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007254 vs STK40 — BLOOD_Leukemia

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