Activation of NF-kappaB-inducing kinase activity

Across TCGA patient cohorts, RNA activity of the Activation of NF-kappaB-inducing kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP8L, SPN, and TRIM21, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of NF-kappaB-inducing kinase activity activity versus AKAP8L in GBM (Pearson r = -0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AKAP8L →	-0.239	-0.043	<.001	<.001	3	7
LSCC	SPN →	+0.427	+0.046	<.001	<.001	3	7
HNSC	TRIM21 →	+0.582	+0.066	<.001	<.001	3	6
COAD	CARD16 →	+0.455	+0.035	<.001	<.001	3	6
COAD	CD74 →	+0.534	+0.027	<.001	.008	3	6
GBM	ARHGAP15 →	+0.587	+0.045	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007250 vs AKAP8L — GBM

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