Activation of NF-kappaB-inducing kinase activity

Across TCGA cell cohorts, RNA activity of the Activation of NF-kappaB-inducing kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBFB, DHX33, and OASL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of NF-kappaB-inducing kinase activity activity versus CBFB in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CBFB →	+1.239	+1.575	.004	.006	3	6
BLOOD_Lymphoma	DHX33 →	+0.817	+0.684	.001	.004	2	6
LARGE_INTESTINE	OASL →	-1.787	-0.686	<.001	.004	3	5
BREAST	RPA2 →	+0.803	+1.245	.003	<.001	3	5
SOFT_TISSUE	CYFIP1 →	+0.796	+1.397	.008	.004	3	5
STOMACH	DAXX →	+0.645	+1.040	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007250 vs CBFB — UPPER_AERODIGESTIVE_TRACT

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