Canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IDH2, ZNF131, and RAB34, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IDH2 grouped by Canonical NF-kappaB signal transduction-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	IDH2 →	-1.191	-1.167	.004	.004	3	5
LARGE_INTESTINE	ZNF131 →	+0.610	+1.101	<.001	<.001	3	3
URINARY_TRACT	RAB34 →	+5.470	+1.852	<.001	<.001	3	3
URINARY_TRACT	TRAF3IP2 →	-1.116	-1.464	.001	<.001	3	3
PANCREAS	IQCD →	-1.213	-0.913	.001	.004	3	3
BREAST	TCTEX1D2 →	-1.011	-0.777	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IDH2 by Canonical NF-kappaB signal transduction activity — KIDNEY

Explore this box plot interactively →