Canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Canonical NF-kappaB signal transduction pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAX, ITPA, and FGFR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAX grouped by Canonical NF-kappaB signal transduction-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MAX →	-0.524	-0.114	.004	.001	3	6
LIVER	ITPA →	+0.173	+0.102	.002	.007	3	5
LUNG_SCLC	FGFR1 →	+0.203	+0.113	.003	.001	3	4
LUNG_SCLC	PTPA →	-0.326	-0.107	.001	.004	3	4
LUNG_SCLC	FOXS1 →	+0.281	+0.121	.009	.005	3	4
LUNG_SCLC	MICA →	-0.156	-0.069	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAX by Canonical NF-kappaB signal transduction activity — BONE

Explore this box plot interactively →