Canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC32, SCLY, and FASTKD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Canonical NF-kappaB signal transduction activity versus CCDC32 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CCDC32 →	-0.960	-0.321	.004	.002	3	7
STOMACH	SCLY →	-1.095	-0.455	.002	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	FASTKD2 →	-0.757	-0.330	<.001	.002	3	6
BREAST	TMPO →	-0.684	-0.264	.002	.002	3	6
BREAST	METTL8 →	-0.622	-0.189	.001	.008	3	6
OVARY	GTF2E2 →	-0.689	-0.316	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007249 vs CCDC32 — UPPER_AERODIGESTIVE_TRACT

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