Canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Canonical NF-kappaB signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBE2V1, EIF3D, and PSMD7, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Canonical NF-kappaB signal transduction activity versus UBE2V1 in URINARY_TRACT (Pearson r = -0.82).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	UBE2V1 →	-3.498	-0.445	<.001	<.001	3	18
URINARY_TRACT	EIF3D →	-2.034	-0.445	<.001	<.001	3	18
OVARY	PSMD7 →	-1.204	-0.333	<.001	<.001	3	18
URINARY_TRACT	PSME3 →	-1.644	-0.494	<.001	<.001	3	18
URINARY_TRACT	RPS12 →	-2.005	-0.434	<.001	<.001	3	18
LARGE_INTESTINE	RPS20 →	-1.849	-0.582	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007249 vs UBE2V1 — URINARY_TRACT

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