Integrin-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Integrin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMP3, ISM1, and MYL9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Integrin-mediated signaling pathway activity versus TIMP3 in COAD (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TIMP3 →	+1.667	+0.245	<.001	<.001	3	3
COAD	ISM1 →	+1.694	+0.238	<.001	.002	3	3
COAD	MYL9 →	+2.014	+0.254	<.001	<.001	3	3
BRCA	MXRA5 →	+1.448	+0.375	<.001	<.001	3	3
COAD	SRPX →	+1.423	+0.238	<.001	<.001	3	3
OV	BMX →	+0.698	+0.341	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007229 vs TIMP3 — COAD

Explore this scatter interactively →