Integrin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Integrin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCFD2, RUFY2, and ABRAXAS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MCFD2 grouped by Integrin-mediated signaling pathway-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MCFD2 →	+0.971	+0.379	.004	.003	3	4
LUNG_NSCLC_LUAD	RUFY2 →	+0.469	+0.200	.004	<.001	3	4
OESOPHAGUS	ABRAXAS1 →	+0.754	+0.306	.002	.003	3	4
CNS	METRN →	+0.982	+0.163	.009	.008	2	4
CNS	MAPKAP1 →	+0.699	+0.188	.003	.003	3	3
CNS	CLTC →	+0.592	+0.161	.004	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MCFD2 by Integrin-mediated signaling pathway activity — PANCREAS

Explore this box plot interactively →