Integrin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Integrin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDLIM5, LAMB3, and TNFAIP8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Integrin-mediated signaling pathway activity versus PDLIM5 in PANCREAS (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PDLIM5 →	+1.567	+0.257	.005	.009	3	7
BREAST	LAMB3 →	+3.663	+0.331	<.001	<.001	3	7
LUNG_SCLC	TNFAIP8 →	+1.266	+0.229	<.001	<.001	3	6
LUNG_SCLC	ANXA2 →	+2.147	+0.284	.003	<.001	2	7
SKIN	HRH1 →	+1.969	+0.310	.001	<.001	3	6
BREAST	ADAM9 →	+1.892	+0.318	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007229 vs PDLIM5 — PANCREAS

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