"Wnt signaling pathway, calcium modulating pathway"

Across TCGA patient cohorts, RNA activity of the "Wnt signaling pathway, calcium modulating pathway" pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WNT5A, RASAL2, and DAPK3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Wnt signaling pathway, calcium modulating pathway" activity versus WNT5A in PDAC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	WNT5A →	+0.627	+0.087	<.001	<.001	3	6
PDAC	RASAL2 →	+0.213	+0.075	.005	.005	3	5
UCEC	DAPK3 →	+0.364	+0.074	<.001	.001	3	5
HNSC	ARHGEF17 →	+0.262	+0.092	<.001	<.001	3	5
BRCA	TLN1_S1164 →	+0.470	+0.063	.002	<.001	3	5
BRCA	MME →	+0.421	+0.080	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007223 vs WNT5A — PDAC

Explore this scatter interactively →