"Wnt signaling pathway, calcium modulating pathway"

Across TCGA patient cohorts, RNA activity of the "Wnt signaling pathway, calcium modulating pathway" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNT5A, PMEPA1, and COL5A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Wnt signaling pathway, calcium modulating pathway" activity versus WNT5A in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WNT5A →	+1.295	+0.214	<.001	.001	2	6
BRCA	PMEPA1 →	+0.885	+0.242	.002	<.001	3	4
BRCA	COL5A1 →	+1.334	+0.185	<.001	.004	3	4
BRCA	ANGPTL2 →	+1.138	+0.214	.002	.001	3	4
BRCA	IRGQ →	+0.477	+0.213	<.001	<.001	3	4
COAD	LINC02761 →	+2.017	+0.610	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007223 vs WNT5A — BRCA

Explore this scatter interactively →