"Wnt signaling pathway, calcium modulating pathway"

Across TCGA cell cohorts, RNA activity of the "Wnt signaling pathway, calcium modulating pathway" pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR119, CTAGE15, and KIRREL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPR119 grouped by "Wnt signaling pathway, calcium modulating pathway"-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GPR119 →	-0.193	-1.355	.001	.001	3	4
KIDNEY	CTAGE15 →	+0.155	+1.317	<.001	<.001	3	4
URINARY_TRACT	KIRREL1 →	-0.225	-1.595	.003	<.001	3	3
LIVER	RCOR2 →	+0.215	+1.197	.004	<.001	3	3
LIVER	RAB37 →	-0.286	-1.346	.005	.003	3	3
LIVER	OAF →	-0.415	-1.622	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPR119 by "Wnt signaling pathway, calcium modulating pathway" activity — STOMACH

Explore this box plot interactively →