Positive regulation of transcription of Notch receptor target

Across TCGA patient cohorts, RNA activity of the Positive regulation of transcription of Notch receptor target pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBM15_T568, ELF2_S191, and LIN52_S28, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription of Notch receptor target activity versus RBM15_T568 in GBM (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RBM15_T568 →	+0.734	+0.779	<.001	<.001	3	4
OV	ELF2_S191 →	+0.994	+1.112	<.001	<.001	3	4
OV	LIN52_S28 →	+1.979	+1.641	<.001	<.001	3	4
BRCA	SRRM2_S1083 →	+0.542	+0.623	<.001	<.001	2	4
BRCA	SRRM2_T2409 →	+0.335	+0.575	<.001	<.001	3	3
GBM	SYN1_S67 →	-0.953	-0.520	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007221 vs RBM15_T568 — GBM

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