Positive regulation of transcription of Notch receptor target

Across TCGA cell cohorts, RNA activity of the Positive regulation of transcription of Notch receptor target pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VASH2, NQO2, and MYO1F, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VASH2 grouped by Positive regulation of transcription of Notch receptor target-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	VASH2 →	+1.460	+1.358	.005	.004	3	4
CNS	NQO2 →	+1.215	+0.939	.001	.003	3	4
SKIN	MYO1F →	-0.319	-0.977	.005	.005	3	4
LARGE_INTESTINE	SCD5 →	+1.833	+1.063	.003	.004	3	4
BLOOD_Leukemia	BACH2 →	+1.583	+1.224	.004	<.001	3	4
BLOOD_Leukemia	TPST1 →	+1.612	+1.165	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VASH2 by Positive regulation of transcription of Notch receptor target activity — STOMACH

Explore this box plot interactively →