Positive regulation of transcription of Notch receptor target

Across TCGA cell cohorts, RNA activity of the Positive regulation of transcription of Notch receptor target pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDELR3, PRPH, and MTERF3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription of Notch receptor target activity versus KDELR3 in BLOOD_Leukemia (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KDELR3 →	+2.605	+1.366	.001	<.001	3	2
BLOOD_Leukemia	PRPH →	+0.252	+0.818	.006	.008	3	2
BLOOD_Leukemia	MTERF3 →	-0.717	-1.286	.006	<.001	3	2
BLOOD_Leukemia	C11orf24 →	+1.564	+0.831	.004	.007	3	2
CNS	FAM89A →	+1.954	+0.270	.006	.009	2	3
BLOOD_Leukemia	POLQ →	-0.845	-0.923	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007221 vs KDELR3 — BLOOD_Leukemia

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