Notch receptor processing

Across TCGA patient cohorts, RNA activity of the Notch receptor processing pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OGDH, MICAL2, and HNRNPUL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Notch receptor processing activity versus OGDH in OV (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	OGDH →	-0.452	-0.190	.003	.003	3	4
LUAD	MICAL2 →	-0.700	-0.576	<.001	<.001	3	4
OV	HNRNPUL1 →	-0.433	-0.177	.006	.007	3	3
OV	TENM4 →	-0.845	-0.196	.006	.002	3	3
OV	TRBV12-5 →	-0.708	-0.215	.004	.006	2	4
CCRCC	KLF13 →	-0.253	-0.495	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007220 vs OGDH — OV

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