Notch receptor processing

Across TCGA cell cohorts, RNA activity of the Notch receptor processing pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED12, CD47, and HAT1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED12 grouped by Notch receptor processing-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MED12 →	+0.395	+0.283	.001	<.001	3	2
OVARY	CD47 →	+0.395	+0.363	.008	.003	3	2
SKIN	HAT1 →	-0.084	-0.349	.001	<.001	3	2
SKIN	HSD17B7 →	+0.156	+0.287	.002	.002	3	2
SKIN	CDH11 →	+0.219	+0.284	.003	.003	3	2
SKIN	PDCL2 →	+0.192	+0.407	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED12 by Notch receptor processing activity — OVARY

Explore this box plot interactively →