Notch receptor processing

Across TCGA cell cohorts, RNA activity of the Notch receptor processing pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FYTTD1, CLEC16A, and HYAL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Notch receptor processing activity versus FYTTD1 in LUNG_NSCLC_LUAD (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FYTTD1 →	-0.629	-0.166	.005	<.001	3	4
SKIN	CLEC16A →	-0.406	-0.287	.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	HYAL3 →	-0.905	-0.193	.002	.004	3	3
LUNG_SCLC	EXO1 →	+0.919	+0.337	.002	.005	3	2
OVARY	PLEKHA2 →	-3.384	-0.282	<.001	.001	3	2
SKIN	TMEM9 →	-0.570	-0.296	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007220 vs FYTTD1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →