Neuropeptide signaling pathway

Across TCGA patient cohorts, RNA activity of the Neuropeptide signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CPE, HLA-DPB1, and NUMA1_S2047, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuropeptide signaling pathway activity versus CPE in PDAC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CPE →	+0.402	+0.019	.002	.001	3	4
LSCC	HLA-DPB1 →	-0.302	-0.031	.006	.001	3	4
LSCC	NUMA1_S2047 →	-0.609	-0.035	.001	<.001	3	4
LSCC	PLEK →	-0.290	-0.026	<.001	.008	3	4
GBM	FAM160B2 →	+0.139	+0.028	.003	.001	3	3
COAD	SLC25A4 →	+0.523	+0.024	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007218 vs CPE — PDAC

Explore this scatter interactively →