Neuropeptide signaling pathway

Across TCGA cell cohorts, RNA activity of the Neuropeptide signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS51, KIFBP, and PHC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuropeptide signaling pathway activity versus VPS51 in PANCREAS (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	VPS51 →	+0.655	+1.502	<.001	<.001	3	5
STOMACH	KIFBP →	+1.343	+1.814	.005	<.001	3	4
PANCREAS	PHC2 →	+0.640	+1.204	.007	.001	2	5
URINARY_TRACT	PDLIM4 →	-4.980	-1.548	<.001	.001	3	4
PANCREAS	TIRAP →	+0.965	+1.253	<.001	<.001	3	4
PANCREAS	CDYL →	+0.713	+1.476	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007218 vs VPS51 — PANCREAS

Explore this scatter interactively →