Tachykinin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Tachykinin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF4B, SNTB2_S95, and SPTBN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tachykinin receptor signaling pathway activity versus EIF4B in BRCA (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EIF4B →	-0.272	-0.044	.006	.004	3	4
COAD	SNTB2_S95 →	+0.271	+0.053	<.001	.007	3	4
BRCA	SPTBN1 →	+0.263	+0.043	<.001	.003	3	4
CCRCC	UBA5 →	-0.187	-0.045	.002	.001	3	4
COAD	CAVIN2_S332 →	+0.882	+0.098	<.001	<.001	3	4
CCRCC	FAM122A_S147 →	+0.213	+0.057	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007217 vs EIF4B — BRCA

Explore this scatter interactively →